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This methylation profile is already obtained in the MBL stage3 and remains reasonably stable after some time. Even so, some CLL have intratumor variability in certain areas, which may change the expression of several genes and aid tumor evolution.seventy one Of Observe, this variability is greater in U-CLL than in M-CLL which is related to increasing range of subclones.7,seventy one
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mutations and trisomy 12 are related to specific reworking of chromatin activation and accessibility areas. A lot more particularly, the epigenomic profile induced by MYD88
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